Utilization of Nitrogenous Precursors for Synthesis of Either Fused or Binary Heterocyclic Systems: Their Bioassay as Antimicrobial and Antitumor: Thesis Abstract

Thesis Abstract Triazines represent a promising scaffold for cancer treatment due to their similarity the biologically active purine and pyrimidine systems. Besides, triazines annulated compounds exist in skeleton of numerous natural synthetic chemotherapeutic agents such as Azanucleosides (6-azacytosine 6-azauracil). Also, triazine derivatives proved display antiviral, anti-inflammatory, antimicrobial antifungal activities. Moreover, it was found that significant wide spectrum anticancer activities against lymphoblastic lung adenocarcinoma A549, leukemia CEM myeloid K562 cell lines. In this regard, newly series triazine-based thiadiazol, thiadiazine, thiadiazepine, pyrazole tetrazepino[b]indol-one, triazolotriazine, tetrazolotriazine, triazinotetrazine, triazinotetrazepinoindole moieties were synthesized, spectrally discussed mechanistically discussed. On other hand, synthesized evaluated different types biological bioassays (Antitumor, Antioxidant Antimicrobial). 33c 37 three human lines (HepG‐2, HCT‐116, MCF‐7) in-vitro The results declared all had potent activity with IC50 values ranging between 10.8 23.4 μM.